Response of the cardiovascular system of cats to ansamycins in the test for depressor substances
Abstract
The article summarises the results of a study which assessed the response of the cardiovascular system of cats to intravenous administration of the ansamycin class of antibiotics using commercial samples and investigational samples of rifampicin and rifabutin for injections. It was shown that intravenous administration of ansamycin solutions was accompanied by hypotensive effects of varying severity. The increase in the rate of rifampicin administration at a dose of 2.0 mg/0.5 ml/kg can result in a greater decrease of the cat’s blood pressure as compared to the effect caused by the administration of the same dose at a rate described in the monograph 1.2.4.0008.15 «Test for depressor substances». Based on the results of the study a mechanism underlying the observed effect was suggested.
About the Authors
L. V. Simutenko
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation
Russian Federation
T. A. Batuashvili
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation
Russian Federation
N. P. Neugodova
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation
Russian Federation
E. O. Stepanyuk
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation
Russian Federation
S. I. Kuleshova
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation
Russian Federation
References
1. General monograph 1.2.4.0008.15. Test for depressor substances. In: The State Pharmacopoeia of the Russian Federation. 13th ed. Moscow; 2015. Available from: http://femb.ru/feml (in Russian).
2. Paget LE, Barnes J. Toxicity Tests. In: Evaluation of Drug Activities: Pharmacometrics. V. 1. London; 1964. P. 135–65.
3. General monograph 1.1.0014.15. Statistical analysis of the results of determination of specific drugs pharmacological activity by biological methods. In: The State Pharmacopoeia of the Russian Federation. 13th ed. Moscow; 2015. Available from: http://femb.ru/feml (in Russian).
4. Sanitary rules SP 2.2.1.3218–14 of 29.08.2014,¹51. Sanitary-epidemic requirements for facilities, equipment and maintenance of experimental biological clinics (vivariums). Available from: http://www.rospotrebnadzor.ru/documents/details.php? ELEMENT_ID=3521 (in Russian).
5. State Standard 33217 – 2014. Guide for maintenance and care of laboratory animals. Terms of maintenance and care of laboratory predatory mammals. Moscow: Standartinform; 2015 (in Russian).
6. Kozlyakov NV, ed. Manual feeding of laboratory animals, birds and primary producers. Moscow; 1968 (in Russian).
7. Guide for maintenance and care of laboratory animals. Appendix A to the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (ETS ¹ 123). St. Petersburg; 2014 (in Russian).
8. Bondarev IM, Ivanov VL, Mozhokina GN, Bentsianov AD, Novoselova VP. Complications and their elimination during the rapid intravenous administration of rifampicin in an experiment. Antibiot Med Biotekhnol. 1987; 32(8): 602–3 (in Russian).
9. Berezhinskaya VV, Dolgova GV, Svinogeeva TP, Zebrev AI. The mechanism of hypotension induced by intravenous administration of rifampicin. Antibiotiki i himioterapiya 1988; 33(10): 771–5 (in Russian).
10. Berezhinskaya VV, Dolgova GV, Firsov AA, Manuilov KK, Nikitin AV. Hypotension caused by intravenous administration of rifampicin, and its dependence on the mode of application of an antibiotic. Antibiotiki i himioterapiya 1990; 35(7): 38–40 (in Russian).
Review
For citations:
Simutenko L.V., Batuashvili T.A., Neugodova N.P., Stepanyuk E.O., Kuleshova S.I. Response of the cardiovascular system of cats to ansamycins in the test for depressor substances. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. 2017;7(1):15-19. (In Russ.)
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