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Use of columns with amine and nitrile sorbents for hydrophylic interaction liquid chromatography

Abstract

The article summarizes the conclusions contained in the authors’ papers on hydrophilic interaction liquid chromatography published in 2010-2016. Chromatographic columns with amine sorbents can perform differently from chromatographic columns with nitrile sorbents in hydrophilic interaction liquid chromatography depending on the products analysed. Chromatographic columns with amine sorbents can be used in the analysis of both hydrophilic compounds and some hydrophobic compounds (nitro compounds, butylhydroxyanisole, parabens). Chromatographic columns with nitrile sorbents can only be used for the analysis of hydrophilic compounds (urea, hydroxyurea) and platinum coordination compounds.

About the Authors

A. S. Osipov
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation


O. A. Popova
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation


T. N. Gretskaya
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation


A. I. Sulimenkova
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation


M. V. Nezdolieva
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation


References

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Review

For citations:


Osipov A.S., Popova O.A., Gretskaya T.N., Sulimenkova A.I., Nezdolieva M.V. Use of columns with amine and nitrile sorbents for hydrophylic interaction liquid chromatography. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. 2017;7(1):9-14. (In Russ.)

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