The possibility of using laser methods for the quality control of highly diluted liquid pharmaceuticals
Abstract
Processing of interferon gamma antibodies, which involves gradual reduction of the concentration, induces the formation of deuterium-stabilized giant heterophase clusters (GHCs) of water characterized by the specific size spectrum and kinetics of formation/decay. An investigation into the formation/decay kinetics of GHCs of water by a 2D light scattering method using topological descriptors allows distinction between various dilutions of protein nanoparticles, in particular interferon gamma antibodies, and similar dilutions of glycine buffer (control). The possibility of analytical control of highly diluted pharmaceuticals is currently under discussion. The method may therefore find potential applications in the manufacturing control of ultrahighly diluted pharmaceuticals and express quality analysis.
About the Authors
A. V. Syroeshkin
Peoples’ Friendship University of Russia, Medical Institute
Russian Federation
Russian Federation
T. V. Pleteneva
Peoples’ Friendship University of Russia, Medical Institute
Russian Federation
Russian Federation
M. A. Morozova
Peoples’ Friendship University of Russia, Medical Institute
Russian Federation
Russian Federation
E. V. Uspenskaya
Peoples’ Friendship University of Russia, Medical Institute
Russian Federation
Russian Federation
O. V. Titorovich
Peoples’ Friendship University of Russia, Medical Institute
Russian Federation
Russian Federation
E. V. Lesnikov
Russian Metrological Institute of Technical Physics and Radio Engineering
Russian Federation
Russian Federation
V. I. Dobrovolsky
Russian Metrological Institute of Technical Physics and Radio Engineering
Russian Federation
Russian Federation
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Review
For citations:
Syroeshkin A.V., Pleteneva T.V., Morozova M.A., Uspenskaya E.V., Titorovich O.V., Lesnikov E.V., Dobrovolsky V.I. The possibility of using laser methods for the quality control of highly diluted liquid pharmaceuticals. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. 2016;(3):31-36. (In Russ.)
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