The role of NO in signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury
Abstract
Many recent studies have confirmed the effect of NO and that its relative signaling pathway is important for preconditioning of the cardioprotective effect. Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury is considered to be the ultimate goal of cardioprotection. During preconditioning, signaling is initiated from the sarcolemmal membrane and then spread into the cytoplasm via many series of enzymes, including nitric oxide synthase (NOS), soluble guanylyl cyclase (sGC), and protein kinase G (PKG). As a result, the signal is transmitted into the mitochondria, where the cardioprotective effect occurs. It is now well established that mitochondria act to protect the heart against ischemia-reperfusion injury via the opening of the mitochondrial ATP-sensitive K+ channel and the inhibition of mitochondrial permeability transition. This knowledge may be useful in developing novel strategies for clinical cardioprotection from ischemia-reperfusion injury.
About the Authors
L. M. Danilenko
Federal State Autonomous Educational Institution of Higher Professional Education «Belgorod State National Research University»
Russian Federation
Russian Federation
M. V. Pokrovskiy
Federal State Autonomous Educational Institution of Higher Professional Education «Belgorod State National Research University»
Russian Federation
Russian Federation
T. A. Denysyuk
Kursk State Medical University
Russian Federation
Russian Federation
I. M. Kolesnik
Federal State Autonomous Educational Institution of Higher Professional Education «Belgorod State National Research University»
Russian Federation
Russian Federation
S. A. Alekhin
Federal State Autonomous Educational Institution of Higher Professional Education «Belgorod State National Research University»
Russian Federation
Russian Federation
References
1. Downey JM, Davis AM, Cohen MV. Signaling pathways in ischemic preconditioning. Heart Fail Rev. 2007; 12: 181–8.
2. Stefano G, Esch T, Bilfinger T, et al. Proinflammation and preconditioning protection are part of a common nitric oxide mediated process. Med Sci Monit. 2010; 16(6): 125–30.
3. Williams MW, Taft CS, Ramnauth S, et al. Endogenous nitric oxide (NO) protects against ischaemia-reperfusion injury in the rabbit. Cardiovasc Res. 1995; 30(1): 79–86.
4. Zhao I, Weber PA, Smith JR, et al. Role of inducible nitric oxide synthase in pharmacological “preconditioning” with monophosphoryl lipid. A J Mol Cell Cardiol. 1997; 29(6): 1567–76.
5. Foster MW, Stamler JS. New insight into protein S-nitrosylation: Mitochondria as a model system. J Biol Chem. 2004; 279(24): 25891–7.
6. Wang H, Kohr MJ, Wheeler DG, et al. Endothelial nitric oxide synthase decreases decreases beta-adrenergic responsiveness via inhibition of the L-type Ca2+current. Am J Physiol Heart Circ Physiol. 2008; 294(3): 1473–80.
7. Yang XM, Krieg T, Cui L, et al. NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO. J Mol Cell Cardiol. 2004; 36: 411–21.
8. Nakano A, Liu GS, Heusch G, et al. Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning. J Mol Cell Cardiol. 2000; 32(7): 1159–67.
9. Kolesnik IM, Pokrovskiy MV, Lazarenko VA, et al. The influence of distant preconditioning on the survival of ischemic tissues. Vestnik eksperimentalnoy i klinicheskoy hirurgii 2010; 3(3): 214–7 (in Russian).
10. Wang Y, Guo Y, Zhang SX, et al. Ischemic preconditioning upregulates inducible nitric oxide synthase in cardiac myocyte. J Mol Cell Cardiol. 2002; 34(1): 5–15.
11. Weerateerangkul Р, Chattipakorn S, Chattipakorn N. Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia- reperfusion injury Med Sci Monit. 2011; 17(2):16-24.
12. Guo Y, Li Q, Wu WJ, et al. Endothelial nitric oxide synthase is not necessary for the early phase of ischemic preconditioning in the mouse. J Mol Cell Cardiol. 2008; 44: 496–501.
13. Du Toit EF, Genade S, Carlini S, et al. Efficacy of ischaemic preconditioning in the eNOS overexpressed working mouse heart model. Eur J Pharmacol. 2007; 556(1–3): 115–20.
14. Lin J, Steenbergen C, Murphy E, et al. Estrogen receptor-β activation results in S-nitrosylation of proteins involved in cardioprotection. Circulation 2009; 120: 245–54.
15. Javadov S, Karmazyn M, Escobales N. Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases. J Pharmacol Exp Ther. 2009; 330(3): 670–78.
16. Danilenko LM, Pokrovskiy MV, Novikov OO, et al. Anti-inflammatory effects of distant ischemic preconditioning in combination with recombinant erythropoietin. Nauchnye vedomosti BelGU. Ser. Meditsina. Farmatsiya 2011; 4, issue 13/2: 49-53 (in Russian).
17. Danilenko LM, Pokrovskiy MV, Novikov OO, et al. Evaluation of antioxidant and antiischemic activity in the series of 3-(2,2,2-trimethylhydrazinium) propionate. Available from: www.science-education.ru/104-6836 (in Russian).
18. Gumanova NG, Artyushkova EB, Metelskaya VA, et al. Effect of antioxidants and resveratrol Q510 on the regulatory function of the endothelium in rats with simulated arterial hypertension. Bulleten eksperimentalnoy biologii i meditsiny 2012; 6(143): 619–22 (in Russian).
19. Kochkarov VI, Pokrovskiy MV, Korneev MM, et al. Endothelioprotective effects of resveratrol and its combination with enalapril and losartan in experimental modeling deficiency of nitric oxide. Kubanskiy nauchny meditsinskiy vestnik 2006; 9: 150–2 (in Russian).
20. Salloum F, Yin C, Xi L, et al. Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart. Circ Res. 2003; 92(6): 595–7.
21. Das A, Xi L, Kukreja RC. Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem. 2005; 280(13): 944–55.
Review
For citations:
Danilenko L.M., Pokrovskiy M.V., Denysyuk T.A., Kolesnik I.M., Alekhin S.A. The role of NO in signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. 2015;(2):40-44. (In Russ.)
Views:
593
Email this article 