Differences in the pharmacokinetics of ibuprofen in monoand multi-component drugs

The article reports the results of the study which investigated the pharmacokinetics of mono- and multi-component ibuprofen-containing drugs following single oral administration to healthy volunteers. Plasma concentration of ibuprofen was determined by HPLC with spectrophotometric detection. The main pharmacokinetic parameters - C_max, T_max, AUC_0-t, AUC_0-¥, MRT, K_el, T_Ѕ - were calculated after single oral administration of the tested drugs. The pharmacokinetics of Ibuprofen/mono and Ibuprofen (pitofenone+fenpiverinium bromide) after single administration did not demonstrate any statistically significant differences, while the combination drug Ibuprofen/paracetamol did have statistically significant differences in pharmacokinetics as compared to the monocomponent Ibuprofen drug.

ибупрофен, нестероидные противовоспалительные средства, высокоэффективная жидкостная хроматография, фармакокинетика, монопрепарат, комбинированный препарат, ibuprofen, nonsteroidal anti-inflammatory drugs, high performance liquid chromatography, pharmacokinetics, monocomponent drug, combination drug

1. Mazaleuskaya LL, Theken KN, Gong L, Thorn CF, FitzGerald GA, Altman RB, Klein TE. PharmGKB summary: ibuprofen pathways. Pharmacogenet Genomics. 2015; 25(2): 96–106.

2. Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults. Neurology 2012; 78(17): 1346–53.

3. Hersh EV, Kane WT, O’Neil MG, Kenna GA, Katz NP, Golubic S, et al. Prescribing recommendations for the treatment of acute pain in dentistry. Compend Contin Educ Dent. 2011; 32(3): 24–30.

4. Brain P, Leyva R, Doyle G, Kellstein D. Onset of analgesia and efficacy of ibuprofen sodium in postsurgical dental pain. Clin J Pain. 2015; 31(5): 444–50.

5. Khalifa N, El-Husseini T, Morrah A, Mostafa E, Hamoud H. Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt. Open Access Rheumatol. 2014; (6): 49–56.

6. Beaver WT. Review of the analgesic efficacy of ibuprofen. Int J Clin Pract. 2003; (135): 13–7.

7. Berry H, Hutchinson DR. Tizanidine and ibuprofen in acute low-back pain: results of a double-blind multicentre study in general practice. J Int Med Res. 1988; 16(2): 83–91.

8. Baranova LN, Kupryashina NV, Lvova LV, Mazurenko DV, Morozenko OA, Muratkhuzina AR, et al. Efficacy and safety of fixed ibufprofen/paracetamol combination in fever and pain syndromes in ambulatory practice. Clinical Pharmacology and Therapy 2014; (4): 95–8 (in Russian).