Determination of the activity of drug-metabolizing enzymes - the prospects for their use in clinical practice
Abstract
One of the common issues of modern medicine is the risk of adverse drug effects when administering certain medicines. The causes of these effects may be various, but they mostly occur because of increased or decreased activity of xenobiotic-metabolizing enzymes, based on cytochrome P450 isoenzyme system (also known as CYP). For the date there is a number of different ways to determine the activity of the mentioned system in specific patient. The authors have studied the basic methods of determining the activity of drug-metabolizing enzymes and the approaches to their introduction into clinical practice, as well as the prospects of using them for the purpose of personalization of pharmacy and pharmacotherapy rationalization.
About the Authors
V. V. Smirnov
Scientific Centre for Expert Evaluation of Medicinal Products; I. M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
E. A. Egorenkov
I. M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
L. M. Krasnykh
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation
Russian Federation
G. F. Vasilenko
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation
Russian Federation
G. V. Ramenskaya
Scientific Centre for Expert Evaluation of Medicinal Products; I. M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Smirnov V.V., Egorenkov E.A., Krasnykh L.M., Vasilenko G.F., Ramenskaya G.V. Determination of the activity of drug-metabolizing enzymes - the prospects for their use in clinical practice. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. 2016;(4):28-32. (In Russ.)
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