Production Process of Canada Goldenrod Herb (Solidago canadensis) Tincture and Extract

INTRODUCTION. Pre-treatment of local herbal substances is an essential growth vector  in  pharmaceutical  industry.  Canada  goldenrod  (Solidago  canadensis  L.)  is a promising source of anti-inflammatory and diuretic substance widespread in Russia and Belarus. Pre-treatment of herbal substances increases the yield of biologically active substances (in particular flavonoids) during extraction, a trait useful for obtaining tinctures and extracts of Canada goldenrod herbs.

AIM. This study aimed to develop processing technology of tinctures and extracts obtained from pre-treated Canada goldenrod allowing to increase the content of flavonoids.

MATERIALS AND METHODS. Canada goldenrod herb was the study object. Four pre-treatment options were studied: heat pre-treatment, defatting, and their combinations. The content of flavonoids was determined by high-performance liquid chromatography. Gas chromatography was used to define residual organic solvents.

RESULTS. The highest yield of flavonoids in tinctures was observed with ethanol volume fraction of 60–70%, raw materials to extractant ratio 1 g to 25 ml, grinding degree of raw materials 2,000 μm, and a settling time of the primary extract no more than four days for remaceration. The highest content of flavonoids in dry extracts is achieved with 90% relative distillation volume, 80 °C distillation temperature, 40 min minimum distillation time, 6 cm thickness of the distilled layer, and no more than 4 days settling time of the primary extract. The highest yield of flavonoids in the tincture is observed in heat pre-treatment of Canada goldenrod herb and in pre-treatment defatting of the herbal raw material for the dry extract.

CONCLUSIONS. Optimal technological parameters for production of Canada goldenrod herb tinctures and extracts have been established. The above technologies developed considering pre-treatment stage can be used to produce the specified extracts of Canada goldenrod herb enriched with flavonoids.

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