Блок-сополимеры этиленоксида и пропиленоксида: перспективы применения в отечественной медицине и фармации

Блок-сополимеры этиленоксида и пропиленоксида (блок-сополимеры ЭО и ПО), также называемые плюрониками, полоксамерами или проксанолами — это полимерные неионогенные поверхностно-активные вещества с высоким гидрофильно-липофильным балансом, являющиеся одними из самых востребованных современных вспомогательных веществ в производстве лекарственных средств. Они используются как при производстве традиционных лекарственных форм (жидких, мягких, твердых), так и в составе систем направленной доставки. Это связано с наличием у таких блок-сополимеров, помимо солюбилизирующей, эмульгирующей, гелеобразующей и других способностей, термореверсивных свойств, которые необходимы при создании in situ систем и технологий 3D-печати.

Цель работы — оценка перспектив применения блок-сополимеров ЭО и ПО в медицинских целях, а также анализ номенклатуры лекарственных препаратов, содержащих блок-сополимеры ЭО и ПО, зарегистрированных в Российской Федерации.

В настоящем обзоре проанализирован реестр зарегистрированных в Российской Федерации лекарственных средств, содержащих полоксамеры, приведен перечень крупнейших мировых производителей блок-сополимеров ЭО и ПО и изучена возможность применения полоксамеров в медицинских целях. На сегодня в мире насчитывается более десяти химических концернов и компаний, производящих блок-сополимеры ЭО и ПО для фармацевтических, биотехнологических и других отраслей. Отмечено, что полоксамеры входят в состав более шестидесяти препаратов на российском фармацевтическом рынке, что свидетельствует о необходимости импортозамещения данных компонентов.

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