vedomostiregmedРегуляторные исследования и экспертиза лекарственных средствRegulatory Research and Medicine Evaluation3034-30623034-3453Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)vedomostiregmed-93Research ArticleСТАНДАРТИЗАЦИЯ И КОНТРОЛЬ КАЧЕСТВА ЛЕКАРСТВЕННЫХ СРЕДСТВSTANDARDIZATION AND QUALITY CONTROL OF MEDICINESОпределение содержания алюминия в цветках ромашки аптечной методом атомно-эмиссионной спектрометрии с индуктивно связанной плазмойDetermination of aluminium in chamomile flowers by inductively coupled plasma-atomic emission spectrometryЩукинВ. М.ShchukinV. M.noemail@neicon.ruСевериноваЕ. Ю.SeverinovaE. Yu.noemail@neicon.ruКузьминаН. Е.KuzminaN. E.noemail@neicon.ruЯшкирВ. А.YashkirV. A.noemail@neicon.ruНаучный центр экспертизы средств медицинского примененияРоссияScientific Centre for Expert Evaluation of Medicinal ProductsRussian Federation201613022018034952Copyright © Щукин В.М., Северинова Е.Ю., Кузьмина Н.Е., Яшкир В.А., 20182018Щукин В.М., Северинова Е.Ю., Кузьмина Н.Е., Яшкир В.А.Shchukin V.M., Severinova E.Y., Kuzmina N.E., Yashkir V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vedomostincesmp.ru/jour/article/view/93

В статье представлены результаты измерения содержания алюминия в цветках ромашки аптечной отечественных фирм-производителей. Проведен сравнительный анализ кумулятивной способности к алюминию различных лекарственных растений. Показано, что ромашка аптечная характеризуется повышенной устойчивостью к избыточным концентрациям алюминия по сравнению с другими видами лекарственного растительного сырья.

The article presents the results of determining aluminum in Chamomile flowers by domestic manufacturers. A comparative analysis of the ability to accumulate aluminum for various medicinal plants has been performed. It has been shown that chamomile is defined by increased resistance to excessive concentrations of aluminum in comparison to other herbal substances.

токсичность соединений алюминияцветки ромашки аптечнойлекарственное растительное сырьеметод атомно-эмиссионной спектрометрии с индуктивно связанной плазмойaluminum compounds toxicityChamomile flowersherbal substancesinductively coupled plasma-atomic emission spectrometryReferencesКузьмина НЕ, Щукин ВМ, Северинова ЕЮ, Яшкир ВА, Меркулов ВА. Изменение подходов к нормированию содержания тяжелых металлов в лекарственном растительном сырье и лекарственных растительных препаратах. Химико-фармацевтический журнал 2015; 49(7): 52-6.Kuzmina NE, Shchukin VM, Severinova EYu, Yashkir VA, Merkulov VA. Changing attitudes to the content of heavy metals in herbal drugs and herbal drug preparations. Himiko-farmatsevticheskiy zhurnal 2015; 49(7): 52–6 (in Russian).Hodgson E, ed. A textbook of modern toxicology. 4th ed. New Jersey: John Wiley & Sons, Inc. Hoboken; 2010.Hodgson E, ed. A textbook of modern toxicology. 4th ed. New Jersey: John Wiley & Sons, Inc. Hoboken; 2010.Toxicological profile for aluminium. Atlanta: Public Health Services Agency for Toxic Substances and Disease Registry; 2008.Toxicological profile for aluminium. Atlanta: Public Health Services Agency for Toxic Substances and Disease Registry; 2008.Golub MS, Domingo JL. What we know and what we need to know about developmental aluminum toxicity. Journal of Toxicology and Environmental Health 1996; 48(6): 585-97.Golub MS, Domingo JL. What we know and what we need to know about developmental aluminum toxicity. Journal of Toxicology and Environmental Health 1996; 48(6): 585–97.Шугалей ИВ, Гарабаджиу АВ, Илюшин МА, Судариков АМ. Некоторые аспекты влияния алюминия и его соединений на живые организмы. Экологическая химия 2012; 21(3): 172-86.Shugaley IV, Garabadzhiu AV, Ilyushin MA, Sudarikov AM. Some aspects of the effect of aluminum and its compounds on living organisms. Ekologicheskaya himiya 2012; 21(3): 172–86 (in Russian).Walton JR. Aluminum’s involvement in the progression of Alzheimer’s disease. J. of Alzheimer’s disease 2013; 35: 7-43.Walton JR. Aluminum’s involvement in the progression of Alzheimer’s disease. J. of Alzheimer’s disease 2013; 35: 7–43.Evaluation of certain food additives and contaminants. In: Sixty-seventh report of the joint FAO / WHO Expert Committee on Food Additives, WHO Technical Report Series 940. 2007. Available from: http://www.who.int/ipcs/publications/jecfa/reports/trs940.pdfEvaluation of certain food additives and contaminants. In: Sixty-seventh report of the joint FAO/WHO Expert Committee on Food Additives, WHO Technical Report Series 940. 2007. Available from: http://www.who.int/ipcs/publications/jecfa/reports/trs940.pdfGreger JL. Aluminium content of the American diet. Food technology 1985; 39: 73-80.Greger JL. Aluminium content of the American diet. Food technology 1985; 39: 73–80.Shu WS, Zhang ZQ, Lan CY, Wong MH. Fluoride and aluminum concentrations of tea plants and tea products from Sichuan Province, PR China. Chemosphere 2003; 52: 1475-82.Shu WS, Zhang ZQ, Lan CY, Wong MH. Fluoride and aluminum concentrations of tea plants and tea products from Sichuan Province, PR China. Chemosphere 2003; 52: 1475–82.Sčančar J, Stibilj V, Milačič R. Determination of aluminium in Slovenian foodstuffs and its leachability from aluminium-cookware. Food Chemistry 2004; 85: 151-7.Sèanèar J, Stibilj V, Milaèiè R. Determination of aluminium in Slovenian foodstuffs and its leachability from aluminium-cookware. Food Chemistry 2004; 85: 151–7.Basgel S, Erdemoģlu SB. Determination of mineral and trace elements in some medicinal herbs and their infusion consumed in Turkey. Science of the total environment 2006; 359: 82-9.Basgel S, Erdemoìlu SB. Determination of mineral and trace elements in some medicinal herbs and their infusion consumed in Turkey. Science of the total environment 2006; 359: 82–9.Senila M, Drolc A, Pintar A, Senila L, Levei E. Validation and measurement uncertainty evaluation of the ICP-OES method for the multi-elemental determination of essential and nonessential elements from medicinal plants and their aqueous extracts. J. of Analytical Science and Technology 2014; 5: 37.Senila M, Drolc A, Pintar A, Senila L, Levei E. Validation and measurement uncertainty evaluation of the ICP-OES method for the multi-elemental determination of essential and nonessential elements frommedicinal plants and their aqueous extracts. J. of Analytical Science and Technology 2014; 5: 37.Barin JS, Pereira JSF, Mello PA, Knorr CL, Moraes DP, Mesko MF, et al. Focused microwave-inducted combustion for digestion of botanical samples and metals determination by ISP OES and ICP-MS. Talanta 2012; 94: 308-14.Barin JS, Pereira JSF, Mello PA, Knorr CL, Moraes DP, Mesko MF, et al. Focused microwave-inducted combustion for digestion of botanical samples and metals determination by ISP OES and ICP-MS. Talanta 2012; 94: 308–14.Malik J, Szakova J, Drabek O, Balik J, Kokoska L. Determination of certain micro and macroelements in plant stimulants and their infusions. Food Chem. 2008; 111: 520-5.Malik J, Szakova J, Drabek O, Balik J, Kokoska L. Determination of certain micro and macroelements in plant stimulants and their infusions. Food Chem. 2008; 111: 520–5.Özcan MM, Akbulut M. Estimation of minerals, nitrate and nitrite contents of medicinal and aromatic plants used as spices, condiments and herbal tea. Food Chem. 2007; 106: 852-8.Özcan MM, Akbulut M. Estimation of minerals, nitrate and nitrite contents of medicinal and aromatic plants used as spices, condiments and herbal tea. Food Chem. 2007; 106: 852–8.Leśniewicz A, Jaworska K, Źyrnicki W. Macro- and micro-nutrients and their bioavailability in polish herbal medicaments. Food Chem. 2006; 99: 670-9.Leoeniewicz A, Jaworska K, yrnicki W. Macro- and micro-nutrients and their bioavailability in polish herbal medicaments. Food Chem. 2006; 99: 670–9.Queralt I, Ovejero M, Carvalho ML, Marques AF, Llabrěs JM. Quantitative determination of essential and trace element content of medicinal plants and their infusions by XRF and ICP techniques. X-ray Spectrom. 2005; 34: 213-7.Queralt I, Ovejero M, Carvalho ML, Marques AF, Llabrìs JM. Quantitative determination of essential and trace element content of medicinal plants and their infusions by XRF and ICP techniques. X-ray Spectrom. 2005; 34: 213–7.Raźić S, Onjia A, Ðogo S, Slavković L, Popović A. Determination of metal content in some herbal drugs - Empirical and chemometric approach. Talanta 2005; 67: 233-9.RaŸiæ S, Onjia A, Ðogo S, Slavkoviæ L, Popoviæ A. Determination of metal content in some herbal drugs — Empirical and chemometric approach. Talanta 2005; 67: 233–9.Гравель ИВ, Шойхет ЯН, Яковлев ГП, Самылина ИА. Фармакогнозия. Экотоксиканты в лекарственном растительном сырье и фитопрепаратах. М.: ГЭОТАР-Медиа; 2012.Gravel IV, Shoyhet YaN, Yakovlev GP, Samylina IA. Pharmacognosy. Ecotoxicants in medicinal herbs and phytopreparations. Moscow: GEOTAR-Media; 2012 (in Russian).Elemental impurities - procedures. General chapter <<233>>, USP 37/NF32. 2014. Available from: http://www.uspnf.com/.Elemental impurities — procedures. General ñhapter <233>, USP 37/NF32. 2014. Available from: http://www.uspnf.com/.Envitomental Protection Agency. Method 3052, SW-846, 1996.Envitomental Protection Agency. Method 3052, SW-846, 1996.Амосова НБ, Николаева ОН, Сынзыныс БИ. Механизмы алюмотолерантности у культурных растений. Сельскохозяйственная биология 2007; (1): 36-42.Amosova NB, Nikolaeva ON, Syzynys BI. Mechanisms of aluminium tolerance in cultivated plants. Selskohozyaistvennaya biologiya 2007; (1): 36–42 (in Russian).

The authors declare that there are no conflicts of interest present.