vedomostiregmedРегуляторные исследования и экспертиза лекарственных средствRegulatory Research and Medicine Evaluation3034-30623034-3453Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)10.30895/1991-2919-2023-527vedomostiregmed-527Research ArticleСТАНДАРТИЗАЦИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВSTANDARDISATION OF MEDICINESОсобенности элементного состава ламинарии слоевищ (Laminariae thalli) различного происхожденияElemental Composition of Kelp Thalli (Laminariae thalli) of Various Originshttps://orcid.org/0000-0001-9440-0950ЩукинВ. М.ShchukinV. M.

Щукин Виктор Михайлович

Петровский б-р, д. 8, стр. 2, Москва, 127051

Victor M. Shchukin

8/2 Petrovsky Blvd, Moscow 127051

schukin@expmed.ruhttps://orcid.org/0000-0002-4813-4740ХорольскаяЕ. А.KhorolskayaE. A.

Хорольская Елена Александровна

Петровский б-р, д. 8, стр. 2, Москва, 127051

Elena A. Khorolskaya

Elena A. Khorolskaya

8/2 Petrovsky Blvd, Moscow 127051

blinkovaea@expmed.ruhttps://orcid.org/0000-0002-9133-0835КузьминаН. Е.Kuz’minaN. E.

Кузьмина Наталия Евгеньевна - доктор химических наук.

Петровский б-р, д. 8, стр. 2, Москва, 127051

Natalia E. Kuz’mina - Dr. Sci. (Chem.).

8/2 Petrovsky Blvd, Moscow 127051

KuzminaN@expmed.ruhttps://orcid.org/0000-0003-3456-8553РемезоваИ. П.RemezovaI. P.

Ремезова Ирина Петровна - доктор фармацевтических наук, профессор.

Просп. Кирова, д. 33, Пятигорск, 357500

Irina P. Remezova - Dr. Sci. (Pharm.), Professor.

33 Kirov Ave., Pyatigorsk 357500

i.p.remezova@pmedpharm.ruhttps://orcid.org/0000-0001-8353-7863КосенкоВ. В.KosenkoV. V.

Косенко Валентина Владимировна - кандидат фармацевтических наук.

Петровский б-р, д. 8, стр. 2, Москва, 127051

Valentina V. Kosenko - Cand. Sci. (Pharm.).

8/2 Petrovsky Blvd, Moscow 127051

General@expmed.ruФедеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииРоссияScientific Centre for Expert Evaluation of Medicinal ProductsRussian FederationПятигорский медико-фармацевтический институт — филиал Федерального государственного бюджетного учреждения высшего образования «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияPyatigorsk Medical and Pharmaceutical Institute, Branch of the Volgograd State Medical UniversityRussian Federation202326062023132154172Copyright © Щукин В.М., Хорольская Е.А., Кузьмина Н.Е., Ремезова И.П., Косенко В.В., 20232023Щукин В.М., Хорольская Е.А., Кузьмина Н.Е., Ремезова И.П., Косенко В.В.Shchukin V.M., Khorolskaya E.A., Kuz’mina N.E., Remezova I.P., Kosenko V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vedomostincesmp.ru/jour/article/view/527

Содержание токсичных и эссенциальных элементов в слоевищах ламинарии широко варьирует в зависимости от таксономической группы и географических факторов. В связи с широким применением водорослей семейства ламинариевых в медицине, пищевой промышленности и ветеринарии является актуальным изучение зависимости элементного состава слоевищ ламинарии различно го происхождения от места их произрастания.

Цель работы — обобщение и анализ собственных экспериментальных данных и данных литературы об особенностях накопления слоевищами бурых водорослей семейства Laminariaceae эссенциальных, токсичных и потенциально канцерогенных микроэлементов, а также йода.

Материалы и методы

Материалы и методы: в работе исследовано содержание 17 элементов в водорослях Laminaria sp. (Al, As, Cd, Cr, Со, Сu, Fe, Hg, Mn, Mo, Ni, Se, Pb, Sr, V, Zn, I). Экспериментальные исследования проведены на масс-спектрометре с индуктивно-связанной плазмой Agilent 7900. С использованием информационно-аналитических методов были изучены литературные данные в области элементного состава водорослей семейства ламинариевых.

Результаты

Результаты: отражены изменения в классификации бурых водорослей семейства ламинариевых и обобщены сведения о механизмах накопления ими микроэлементов и йода. Определено влияние вида макрофита на ряд биологического поглощения исследованных элементов. Установлены особенности накопления элементных токсикантов различными видами семейства Laminariaceae. С использованием коэффициентов ранговой корреляции Спирмена изучено взаимное влияние элементов на их накопление в ламинариевых водорослях.

Выводы

Выводы: результаты исследования могут быть использованы для реализации риск-ориентированной стратегии контроля качества лекарственных растительных препаратов для снижения поступления в организм человека токсичных элементов. Высказано предположение о необходимости нормирования верхней границы содержания йода в пищевых продуктах на основе ламинарии.

Brown seaweeds (Laminariaceae) vary considerably in the content of toxic and essential elements; these variations depend on the taxonomic group and geographical factors. Seaweeds are extensively used in the food industry and widely applied in medicine for both humans and animals. Therefore, it is relevant to examine the correlation between the elemental composition and the geographical origin of kelp thalli obtained from different sources.

The aim of the study was to collect, collate, and analyse primary and secondary data on the accumulation of essential, toxic and potentially carcinogenic elements, including iodine, in the thalli of brown seaweeds (Laminariaceae).

Materials and methods

Materials and methods. This study investigated the concentrations of 17 elements in Laminaria spp. (Al, As, Cd, Cr, Co, Cu, Fe, Hg, Mn, Mo, Ni, Se, Pb, Sr, V, Zn, and I). Experiments were conducted on an Agilent 7900 inductively coupled plasma mass spectrometer. The authors studied publications on the elemental composition of brown seaweeds (Laminariaceae) using literature search and data analysis methods.

Results

Results. This article reflects the updated classification of brown seaweeds (Laminariaceae) and summarises information about the mechanisms by which iodine and other elements accumulate in the thallus. The authors established species-specific variations in the order of element uptake and in the accumulation of elemental toxicants. The mutual influence of elements on their accumulation in brown seaweeds (Laminariaceae) was evaluated using Spearman’s rank correlation coefficients.

Conclusions

Conclusions. The study results can inform the implementation of a risk-based quality control strategy for herbal medicinal products aimed at reducing human exposure to toxic elements. The authors suggest that the upper limit of iodine content in kelp-based food products should be standardised.

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The authors declare that there are no conflicts of interest present.