vedomostiregmedРегуляторные исследования и экспертиза лекарственных средствRegulatory Research and Medicine Evaluation3034-30623034-3453Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)vedomostiregmed-146Research ArticleОБЗОРЫREVIEWSФармакогенетическое тестирование в оптимизации терапии сахарного диабета 2 типа препаратами сульфонилмочевиныPharmacogenetic testing in the treatment of type 2 diabetes with sulfonylurea drugsГородецкаяГ. И.GorodetskayaG. I.noemail@neicon.ruКукесВ. Г.KukesV. G.noemail@neicon.ruБелковС. А.BelkovS. A.noemail@neicon.ruКазаковР. Е.KazakovR. E.noemail@neicon.ruСереброваС. Ю.SerebrovaS. Yu.noemail@neicon.ruМуслимоваО. В.MuslimovaO. V.noemail@neicon.ruРодинаТ. А.RodinaT. A.noemail@neicon.ruАлександровА. А.AleksandrovA. A.noemail@neicon.ruНаучный центр экспертизы средств медицинского примененияРоссияScientific Centre for Expert Evaluation of Medicinal ProductsRussian Federation20171302201874233241Copyright © Городецкая Г.И., Кукес В.Г., Белков С.А., Казаков Р.Е., Сереброва С.Ю., Муслимова О.В., Родина Т.А., Александров А.А., 20182018Городецкая Г.И., Кукес В.Г., Белков С.А., Казаков Р.Е., Сереброва С.Ю., Муслимова О.В., Родина Т.А., Александров А.А.Gorodetskaya G.I., Kukes V.G., Belkov S.A., Kazakov R.E., Serebrova S.Y., Muslimova O.V., Rodina T.A., Aleksandrov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vedomostincesmp.ru/jour/article/view/146

Проведен анализ данных научной литературы по применению фармакогенетических исследований в оптимизации лечения пациентов с сахарным диабетом 2 типа препаратами сульфонилмочевины (ПСМ). Представлена характеристика современных гипогликемических ПСМ, используемых в терапии сахарного диабета 2 типа, включая описание механизма их действия, а также данные о частоте развития гипогликемий при этом заболевании. Проанализированы основные фармакокинетические показатели ПСМ (биодоступность, связь с белком, метаболиты, элиминация и др.), нежелательные реакции, вызванные данными препаратами. На основе систематизированных данных об участии изоферментов цитохрома Р450 в метаболизме ПСМ, выявлении роли полиморфизма гена, кодирующего данный фермент, продемонстрирована целесообразность проведения фармакогенетического тестирования при лечении пациентов с сахарным диабетом 2 типа ПСМ в комплексе с использованием методики фенотипирования (лозартанового теста).

The article analyses scientific literature on the use of pharmacogenetic testing to optimize sulfonylurea treatment of patients with type 2 diabetes. It describes characteristics of modern sulfonylurea drugs used in the treatment of type 2 diabetes, including their mode of action, and the frequency of associated hypoglycaemia events. The authors analysed the main pharmacokinetic parameters of sulfonylureas (bioavailability, protein binding, metabolites, elimination, etc.), and adverse reactions associated with these drugs. Based on integrated data on Cytochrome P450 isoenzymes role in sulfonylureas metabolism, and determination of the role played by polymorphism of the gene encoding this fragment, the authors demonstrated the usefulness of pharmacogenetic testing combined with phenotypic (losartan) testing in the treatment of patients with type 2 diabetes.

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The authors declare that there are no conflicts of interest present.