vedomostiregmedРегуляторные исследования и экспертиза лекарственных средствRegulatory Research and Medicine Evaluation3034-30623034-3453Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)vedomostiregmed-101Research ArticleРАЗРАБОТКА ЛЕКАРСТВЕННЫХ СРЕДСТВDEVELOPMENT OF MEDICINESБиологические механизмы естественной цитопротекции - перспективное направление создания новых лекарственных препаратов для профилактики и лечения преэклампсииBiological mechanisms of natural cytoprotection - a promising trend in the development of new medicines aimed at prevention and treatment of preeclampsiaПокровскийМ. В.PokrovskyM. V.noemail@neicon.ruГуреевВ. В.GureevV. V.noemail@neicon.ruСтупаковаЕ. Г.StupakovaE. G.noemail@neicon.ruАнцифероваО. Е.AntsiferovaO. E.noemail@neicon.ruЛоктеваТ. И.LoktevaT. I.noemail@neicon.ruЖилинковаЛ. А.ZhilinkovaL. A.noemail@neicon.ruБелгородский государственный национальный исследовательский университетРоссияBelgorod State National Research UniversityRussian FederationКурский областной перинатальный центрРоссияKursk Regional Perinatal CenterRussian FederationКурский институт социального образования (филиал), Российский государственный социальный университетРоссияKursk Institute of Social Education (Branch), Russian State Social UniversityRussian Federation201613022018042027Copyright © Покровский М.В., Гуреев В.В., Ступакова Е.Г., Анциферова О.Е., Локтева Т.И., Жилинкова Л.А., 20182018Покровский М.В., Гуреев В.В., Ступакова Е.Г., Анциферова О.Е., Локтева Т.И., Жилинкова Л.А.Pokrovsky M.V., Gureev V.V., Stupakova E.G., Antsiferova O.E., Lokteva T.I., Zhilinkova L.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vedomostincesmp.ru/jour/article/view/101

Преэклампсия является частым и опасным заболеванием беременных, не имеющим тенденции к снижению. В приведенной статье описывается патогенез преэклампсии в соответствии с последними исследованиями. Одним из перспективных направлений создания лекарственных препаратов для профилактики и лечения преэклампсии может быть активация биологических процессов цитопротекции, возникающих при ишемическом прекондиционировании. Приведены данные экспериментальных исследований и клинические наблюдения, которые позволяют обосновать перспективность указанного направления.

Preeclampsia is a frequent and dangerous disease in pregnancy which has shown no decrease in incidence. The article describes preeclampsia pathogenesis as reported in recent studies. A promising trend in the development of new medicines aimed at prevention and treatment of preeclampsia is the activation of biological processes of cytoprotection which arise during ischemic preconditioning. The article cites experimental and clinical data that help to justify the good potential of this area of research.

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The authors declare that there are no conflicts of interest present.